Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/1915
Título: A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
Autor: Forte, Andreia
Melo, Catarina I.
Bogel-Lukasik, R.
Bogel-Lukasik, Ewa
Palavras-chave: Isoniazid
Ionic liquid
Solubility
Solid–liquid equilibria
Thermochemical properties
Drug
Antibiotic
Data: 2012
Editora: Elsevier
Citação: Forte, Andreia; Melo, Catarina, I.; Bogel-Lukasik, R.; Bogel-Lukasik, E. A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents. In: Fluid Phase Equilibria, 2012, vol. 318, p. 89-95
Resumo: The sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid–liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range.
URI: http://hdl.handle.net/10400.9/1915
ISSN: 0378-3812
Versão do Editor: http://dx.doi.org/10.1016/j.fluid.2012.01.022
Aparece nas colecções:UB - Artigos em revistas internacionais

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