Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/2022
Título: Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties
Autor: Lopes, Luciane C.
Carvalho, João E.
Kakimore, Marise
Vendramini-Costa, Débora B.
Medeiros, Maria Augusta
Spindola, Humberto M.
Ávila-Román, J.
Lourenço, A. M.
Motilva, Virginia
Palavras-chave: Solanum Cernuum Vell.
31-norcycloartanones
Analgesic
Anti-inflammatory
COX-2
Data: 2014
Editora: Springer
Citação: Lopes, Luciane C.; Carvalho, João E.; Kakimore, Marise; Vendramini-Costa, D.B.; Medeiros, Maria A. [et.al.]. Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties. In: Inflammopharmacology, 2014, Vol. 22, nº 3, p. 179-185
Resumo: Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses high levels of COX-2, suggesting its role in inflammatory process, and also a link between chronic inflammation and cancer-associated process. Dichloromethane crude extract (DCE) significantly reduced writhing and stretching induced by 0.8 % acetic acid at a dose of 100, 300, and 600 mg/kg, po; oral administration of different doses of (1) and (2) also displayed significant analgesic and anti-inflammatory effects in the writhing acetic acid test (p < 0.0001). Selected oral doses of both compounds (100 and 50 mg/kg) were assayed in the carrageenan-induced paw edema model. Compound (2) showed significant activity during the early phase (1.5–6 h) and also in the late phase (48 h) (p < 0.01). The anti-nociceptive activity observed for the compounds (1) and (2) and DCE was found to be related to the inhibition of different mediators involved in inflammation and nociceptive process. Both compounds decreas COX-2 protein expression, although only compound (2) reached a significant response (p < 0.05 vs control). However, in vitro Sirtuin 1 activity and TNF-a production in THP-1 macrophages were not affected.
URI: http://hdl.handle.net/10400.9/2022
ISSN: 0925-4692
Versão do Editor: http://dx.doi.org/10.1007/s10787-013-0182-8
Aparece nas colecções:ES - Artigos em revistas internacionais

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