Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/2327
Título: Solubility of pharmaceutical compounds in ionic liquids
Autor: Santos, Ana Duarte dos
Morais, Ana Rita
Melo, Catarina I.
Bogel-Lukasik, R.
Bogel-Lukasik, Ewa
Palavras-chave: Solubility
Solid–liquid equilibria
Ionic Liquids
Thermochemical properties
Partition coefficient
Data: 2013
Editora: Elsevier
Citação: Santos, Ana D. dos; Morais, Ana R.C.; Melo, C.; Bogel-Lukasik, R.; Bogel-Lukasik, E. Solubility of pharmaceutical compounds in ionic liquids. In: Fluid Phase Equilibria, Vol. 356, p. 18-29
Resumo: The solubility of N-acetyl-l-cysteine, coumarin and 4-hydroxycoumarin in alternative solvents was studied in this work. The solid–liquid equilibrium (SLE) measurements have been performed using a dynamic(synthetic) method. Melting points and enthalpies of fusion of the pharmaceutical compounds were acquired using a differential scanning calorimetry (DSC). The solubility of N-acetyl-l-cysteine and 4-hydroxycoumarin in trifluoromethanesulfonate ionic liquids was found to be significantly higher thanin the studied bis(trifluoromethylsulfonyl)amide ionic liquids while coumarin exhibited the oppositebehaviour.The solid–liquid phase equilibria were described using the six different correlation equations whichrevealed a good description with an acceptable standard deviation temperature range.Moreover, the solubility data were used to calculate the 1-octanol/water partition coefficients of thestudied drugs. Coumarin has a high partition coefficient, which is considered to be favourable for a rapidabsorption of compounds once they are in an aqueous solution. N-acetyl-l-cysteine showed oppositeresults for the system with 1-octanol/water.
URI: http://hdl.handle.net/10400.9/2327
ISSN: 0378-3812
Versão do Editor: http://dx.doi.org/10.1016/j.fluid.2013.07.020
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