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Title: Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage
Author: Gonçalves, Carla
Wisecaver, Jennifer H.
Kominek, Jacek
Oom, Madalena Salema
Leandro, Maria José
Shen, Xing-Xing
Opulente, Dana A.
Zhou, Xiaofan
Peris, David
Kurtzman, Cletus P.
Hittinger, Chris Todd
Rokas, Antonis
Gonçalves, Paula
Keywords: Alcoholic fermentation
Fructophilic bacterium
Issue Date: 2018
Publisher: eLife Sciences Publications
Citation: Gonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; []. - Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage. In: eLife, 2018, Vol. 7, p. 1-28
Abstract: ABSTRACT: Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.
Peer review: yes
ISSN: 2050-084X
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Appears in Collections:UB - Artigos em revistas internacionais

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