Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/3051
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dc.contributor.authorGonçalves, Carla-
dc.contributor.authorWisecaver, Jennifer H.-
dc.contributor.authorKominek, Jacek-
dc.contributor.authorOom, Madalena Salema-
dc.contributor.authorLeandro, Maria José-
dc.contributor.authorShen, Xing-Xing-
dc.contributor.authorOpulente, Dana A.-
dc.contributor.authorZhou, Xiaofan-
dc.contributor.authorPeris, David-
dc.contributor.authorKurtzman, Cletus P.-
dc.contributor.authorHittinger, Chris Todd-
dc.contributor.authorRokas, Antonis-
dc.contributor.authorGonçalves, Paula-
dc.date.accessioned2018-09-07T14:33:37Z-
dc.date.available2018-09-07T14:33:37Z-
dc.date.issued2018-
dc.identifier.citationGonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; [et.al.]. - Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage. In: eLife, 2018, Vol. 7, p. 1-28pt_PT
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10400.9/3051-
dc.description.abstractABSTRACT: Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.pt_PT
dc.language.isoengpt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/112802/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147258/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89489%2F2012/PTpt_PT
dc.relationSFRH/BPD/102803/2014pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlcoholic fermentationpt_PT
dc.subjectYeastspt_PT
dc.subjectFructophilic bacteriumpt_PT
dc.titleEvidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineagept_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage28pt_PT
degois.publication.titleeLifept_PT
dc.relation.publisherversionhttps://doi.org/10.7554/eLife.33034pt_PT
dc.peerreviewedyespt_PT
degois.publication.volume7pt_PT
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