Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/703
Título: Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization
Autor: Teixeira, Fátima C.
Antunes, Inês F.
Curto, Maria João Marcelo
Neves, M.
Teixeira, António P. S.
Palavras-chave: Bisphosphonates
Indazole
N-1 and N-2 isomers
Spectroscopic characterization
Data: 2009
Citação: Teixeira, Fátima C.; Antunes, Inês F.; Curto, Maria J. Marcelo; Neves, M; Teixeira, António P. S. Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization. In: Arkivoc,vol XI, 2009, p.69-84
Resumo: Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between the indazole ring and the bisphosphonate group.
URI: http://hdl.handle.net/10400.9/703
Aparece nas colecções:INETI - Artigos em revistas internacionais

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