Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.9/708
Título: Simulating antigenic drift and shift in influenza A
Autor: Fachada, Nuno
Lopes, Vitor V.
Rosa, Agostino
Palavras-chave: Immune system
Influenza A
Simulation
Agent-based modeling
Data: 8-Mar-2009
Citação: Fachada, N.; Lopes, Vitor V.; Rosa, Agostinho. Simulating antigenic drift and shift in influenza A. In: Proceeding of the 24th Annual ACM Symposium on Applied Computing (SAC'2009), Honolulu, Hawaii, USA. ACM, 8-12 March 2009, p. 2093-2100
Resumo: Computational models of the immune system and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present an agent-based model of immune-influenza A dynamics, with focus on low level molecular antigen-antibody interactions, in order to study antigenic drift and shift events, and analyze the virulence of emergent strains. At this stage of the investigation, results are presented and discussed from a qualitative point of view against recent and generally recognized immunology and influenza literature.
URI: http://hdl.handle.net/10400.9/708
Aparece nas colecções:UMOSE - Comunicações em actas de encontros científicos internacionais

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