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Novel Bisphosphonates Derived from 1H-Indazole, 1H-Pyrazolo[3,4-b]Pyridine, and 1H-Pyrazolo[3,4-b]Quinoline

2016Journal article Open access
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dc.contributor.authorTeixeira, Fatima
dc.contributor.authorLucas, Carla
dc.contributor.authorCurto, Maria João Marcelo
dc.contributor.authorTeixeira, António P. S.
dc.contributor.authorDuarte, M. Teresa
dc.contributor.authorAndre, Vania
dc.date.accessioned2016-02-23T11:58:56Z
dc.date.available2016-02-23T11:58:56Z
dc.date.issued2016
dc.description.abstractNovel tetraethyl ethylene-1,1-bisphosphonate esters derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine, and 1H-pyrazolo[3,4-b]quinoline were synthesized by a Michael addition reaction of tetraethyl ethylidene-1,1-bisphosphonate with the corresponding heterocycle, using conventional heating and microwave-assisted methods. The microwave-assisted method provides shorter reaction times and better yields. The hydrolysis of bisphosphonates afforded the corresponding bisphosphonic acids or salt, using concentrated hydrochloric acid or TMSBr/collidine, respectively. All new compounds were fully characterized, and their structures were assigned using 1H, 31P, and 13C NMR and IR spectroscopies and mass spectrometry. The molecular structure of compound 6 was confirmed by X-ray diffraction studies.pt_PT
dc.identifier.citationTeixeira, F.C.; Lucas, C.; Curto, M. João M.; Teixeira, A.P.S.; Duarte, M.T.; André. Novel Bisphosphonates Derived from 1H-Indazole, 1H-Pyrazolo[3,4-b]Pyridine, and 1H-Pyrazolo[3,4-b]Quinoline. In: Heteroatom Chemistry, 2016, Vol. 27, nº 1, p. 3-11pt_PT
dc.identifier.doi10.1002/hc.21282pt_PT
dc.identifier.issn1098-1071
dc.identifier.urihttp://hdl.handle.net/10400.9/2867
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttp://dx.doi.org/10.1002/hc.21282pt_PT
dc.subjectBisphosphonatespt_PT
dc.subjectIndazolept_PT
dc.subjectPyrazolo[3,4-b]pyridinept_PT
dc.subjectPyrazolo[3,4-b]quinolinept_PT
dc.subjectMicrowave-assisted reactionpt_PT
dc.titleNovel Bisphosphonates Derived from 1H-Indazole, 1H-Pyrazolo[3,4-b]Pyridine, and 1H-Pyrazolo[3,4-b]Quinolinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage11pt_PT
oaire.citation.startPage3pt_PT
oaire.citation.titleHeteroatom Chemistrypt_PT
oaire.citation.volume27pt_PT
person.familyNameTeixeira
person.familyNameTeixeira
person.familyNameDuarte
person.familyNameAndre
person.givenNameFatima
person.givenNameAntónio Paulo Silva
person.givenNameMaria Teresa
person.givenNameVania
person.identifier1017457
person.identifier.ciencia-idC014-509B-D1DC
person.identifier.ciencia-id7E16-5ED4-ED6A
person.identifier.ciencia-id5D11-03DB-AB4F
person.identifier.orcid0000-0003-0801-2068
person.identifier.orcid0000-0001-7448-0893
person.identifier.orcid0000-0003-0994-1352
person.identifier.orcid0000-0001-5599-8355
person.identifier.ridN-5456-2014
person.identifier.ridH-8658-2012
person.identifier.ridA-3006-2011
person.identifier.scopus-author-id7102746385
person.identifier.scopus-author-id36856362300
person.identifier.scopus-author-id6505770075
person.identifier.scopus-author-id22233327400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3daa40f1-7bb6-488d-83d9-04a61c655d67
relation.isAuthorOfPublicationd8ff15d1-5d27-4e57-8654-f0f85fd79510
relation.isAuthorOfPublicationd5330a18-4020-4221-a577-b79c4ac6facf
relation.isAuthorOfPublication3f0872a6-ed9b-4c76-8da5-63305689f9e3
relation.isAuthorOfPublication.latestForDiscovery3daa40f1-7bb6-488d-83d9-04a61c655d67

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