Zakrzewska, Malgorzata E.Cal, Pedro M.S.D.Candeias, Nuno R.Lukasik, Rafal M.Afonso, Carlos A.M.Ponte, Manuel NunesGois, Pedro M.P.2013-07-112013-07-112012Zakrzewska, Malgorzata E.; Cal, Pedro M.S.D.; Candeias, Nuno R.; Bogel-Lukasik, R. [et.al.] Intramolecular C–H insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction media. In: Green Chemistry Letters and Reviews, 2012, vol. 5, nº 2, p. 211-2401751-8253http://hdl.handle.net/10400.9/1918In this work, the intramolecular C–H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C–H insertion was also achieved and the β-lactam 14 was obtained in >97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh2(S-PTTL)4. Finally, the dirhodium(II) complex Rh2(OAc)4 was used in two consecutive cycles in which complete conversion to the lactam was observed.engDiazoacetamidesC–H insertionDirhodium(II)LactamsscCO2journal article