Fachada, NunoLopes, Vitor V.Rosa, Agostinho2010-06-242010-06-242009-03-08Fachada, N.; Lopes, Vitor V.; Rosa, Agostinho. Simulating antigenic drift and shift in influenza A. In: Proceeding of the 24th Annual ACM Symposium on Applied Computing (SAC'2009), Honolulu, Hawaii, USA. ACM, 8-12 March 2009, p. 2093-2100http://hdl.handle.net/10400.9/708Computational models of the immune system and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present an agent-based model of immune-influenza A dynamics, with focus on low level molecular antigen-antibody interactions, in order to study antigenic drift and shift events, and analyze the virulence of emergent strains. At this stage of the investigation, results are presented and discussed from a qualitative point of view against recent and generally recognized immunology and influenza literature.engImmune systemInfluenza ASimulationAgent-based modelingconference object