Browsing by Author "Moiteiro, Cristina"
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- Antimicrobial activity of azorean cryptomeria japonica essential oils.Publication . Moiteiro, Cristina; Feio, Sónia; Rojas, R.; Bragança, H.
- Composition and biological activity of the essential oil peruvian lantana camaraPublication . Benites, Julio; Moiteiro, Cristina; Miguel, Graça; Rojo, Leonel; Lopez, José; Venâncio, Florência; Ramalho, Luís; Feio, Sónia; Dandlen, Susana; Casanova, Hugo; Torres, IvanThe composition of the essential oil from Lantana camara L. (Verbenaceae) obtained by hydrodistillation of the aerial parts was examined by GC, GC/MS, and 13C-NMR. The GC analysis showed that carvone is the most abundant monoterpene 75.9%, together with limonene 16.9%, accounting for 92.8% of the oil. The major components were also tested by 13C-NMR analysis of the essential oil. The L. camara oil was assayed against several microorganisms, showing moderate antibacterial activity against the human pathogen Staphylococcus aureus (MIC 200 μg/ml). High antioxidant activity evaluated by the Trolox equivalent antioxidant capacity assay (TEAC) was found (29.0 mmol Trolox/kg) and relative low anti-inflammatory activity due to its weak ability for inhibiting lipoxygenase (IC50 = 81.5 μg/ml).
- Essential oil characterization of two azorean cryptomeria japonica populations and their biological evaluationsPublication . Moiteiro, Cristina; Esteves, Teresa; Ramalho, Luís; Rojas, R.; Alvarez, Sandra; Zacchino, Susana; Bragança, H.Essential oils from foliage, bark and heartwood of Cryptomeria japonica D. Don from Azores Archipelago (Portugal) were analyzed by GC and GC-MS. Two populations, of black and reddish heartwood color, were studied. The main compounds found in the foliage of both populations were ƒÑ-pinene (9.6-29.5%), (+)-phyllocladene (3.5-26.5%), ent-kaur-16-ene (0.2-20.6%), sabinene (0.5-19.9%) and limonene (1.4-11.5%), with a large variation in individual compounds from each population. Heartwood oils were characterized by a high content of cubebol (2.8-39.9%) and epi-cubebol (4.1-26.9%) isomers, which were absent in the foliage. Elemol and eudesmol isomers were found in the foliage and heartwood oils, while (+)-phyllocladene was absent in heartwood. Black and reddish bark oils were composed of the diterpenes dehydroferruginol (1.9-5.1%) and ferruginol (2.6-11.5%), along with the sesquiterpenes ƒÔ-cadinene (10.4-15.9%), ƒÑ-muurolene (3.3-5.4%), epi-zonarene (4.0-5.0%), cubenol (9.3-14.0%), ƒä-muurolol (4.8-10.7%), ƒÒ-eudesmol (3.0-9.9%), ƒ×ƒ{eudesmol (1.9-7.0%) and hedycariol (1.4-6.2%). Azorean C. japonica oils exhibited significant chemical differences compared with native plants from Asia. The essential oils showed moderate antimicrobial activity against the pathogenic fungus Cryptococcus neoformans and human pathogenic bacteria (especially against multidrug-resistant Mycobacterium tuberculosis). The antimicrobial activity of the essential oils may be attributed to compounds such as ent-kaur-16- ne, (+)-phyllocladene, ferruginol and elemol, which are present in different proportions within the complex oil mixture. These results suggest a potential use for C. japonica oils obtained from wood industry leftovers.
- Plectranthus diterpenes against mycobacterium tuberculosisPublication . Rijo, P.; Simões, M. F.; Francisco, A. P.; Rojas, R.; Gilman, R. H.; Vaisberg, A. J.; Moiteiro, Cristina; Rodriguez, B.
- Tuberculostatic activity of marine sesquiterpene (S)-(+)-curcuphenol and semisynthetic derivatesPublication . Moiteiro, Cristina; Gaspar, Helena; Sardinha, João; Ramos, D.; Silva, P. Almeida da