Repository logo
 
Publication

Development of a sustainable, simple, and robust method for efficient l-DOPA extraction

2019Journal article Open access
Simple item page
dc.contributor.authorPolanowska, Katarzyna
dc.contributor.authorLukasik, Rafal M.
dc.contributor.authorKuligowski, Maciej
dc.contributor.authorNowak, Jacek
dc.date.accessioned2020-03-30T16:08:25Z
dc.date.available2020-03-30T16:08:25Z
dc.date.issued2019
dc.description.abstractABSTRACT: l-3,4-dihydroxyphenylalanine (l-DOPA) is a medically relevant compound in Parkinson's disease therapy. Several extraction methods of l-DOPA from beans, including velvet and faba beans, have been described in the literature. However, these methods require the use of strong acids, long extraction times, or complex downstream processing, which makes the extraction of l-DOPA expensive and energy-demanding, limiting its industrial application. In addition, the stability of l-DOPA during the extraction process is critical, further complicating the extraction of adequate amounts of this amino acid. This work is the first report on a simple, rapid, greener, and robust extraction method of l-DOPA. The developed method consists of a quick homogenization step followed by a double extraction with 0.2% v/v acetic acid for 20 min and was applied to faba bean at a ratio of 1:25 with respect to the extracting solvent. This study also investigated the stability of l-DOPA during extraction and thermal treatment. The proposed method demonstrated to be robust and extraordinarily efficient for numerous cultivars of faba bean, velvet bean, and food products containing faba beans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPolanowska, K... [et.al.] - Development of a sustainable, simple, and robust method for efficient l-DOPA extraction. In: Molecules, 2019, Vol. 24(12), article nº 2325pt_PT
dc.identifier.doi10.3390/molecules24122325pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.9/3216
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPolish National Science Centre - 2016/23/N/NZ9/00057pt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/molecules24122325pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectl-DOPApt_PT
dc.subjectExtractionpt_PT
dc.subjectProcessing methodspt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectStabilitypt_PT
dc.titleDevelopment of a sustainable, simple, and robust method for efficient l-DOPA extractionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespt_PT
oaire.citation.volume24pt_PT
person.familyNameLukasik
person.givenNameRafal
person.identifier.orcid0000-0002-7805-5744
person.identifier.ridA-6315-2011
person.identifier.scopus-author-id6506737268
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6a7fdbd9-7961-407e-88d0-15d175ea711d
relation.isAuthorOfPublication.latestForDiscovery6a7fdbd9-7961-407e-88d0-15d175ea711d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Development of a Sustainable Simple and Robust Method for Efficient L-DOPA Extraction.pdf
Size:
588.8 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UB - Artigos em revistas internacionais