New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synthesis and Characterization

Teixeira, Fatima; Lucas, Carla; Curto, Maria João Marcelo; Neves, M.; Duarte, M. Teresa; Andre, Vania; Teixeira, António P. S.

http://hdl.handle.net/10400.9/2033

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Authors

Teixeira, Fatima

Lucas, Carla

Curto, Maria João Marcelo

Neves, M.

Duarte, M. Teresa

Andre, Vania

Teixeira, António P. S.

Abstract(s)

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.

Keywords

Bisphosphonates Spectroscopic characterization Synthesis X-ray diffractometry

URI

http://hdl.handle.net/10400.9/2033

Citation

Teixeira, Fátima C.; Lucas, Carla; Curto, M. João Marcelo, [et.al.]. New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synthesis and Characterization. In: Journal of the Brazilian Chemical Society, 2013, Vol. 24, nº 8, p. 1295-1306