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Solubility of pharmaceutical compounds in ionic liquids
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Orientador(es)
Resumo(s)
The solubility of N-acetyl-l-cysteine, coumarin and 4-hydroxycoumarin in alternative solvents was studied in this work. The solid–liquid equilibrium (SLE)
measurements have been performed using a dynamic(synthetic) method. Melting points and enthalpies of fusion of the pharmaceutical compounds were acquired using a differential scanning calorimetry (DSC). The solubility of N-acetyl-l-cysteine and 4-hydroxycoumarin in trifluoromethanesulfonate ionic liquids was found to be significantly
higher thanin the studied bis(trifluoromethylsulfonyl)amide ionic liquids while coumarin exhibited the oppositebehaviour.The solid–liquid phase equilibria were described using the six different correlation equations whichrevealed a good description with an acceptable standard deviation temperature range.Moreover, the solubility data were
used to calculate the 1-octanol/water partition coefficients of thestudied drugs. Coumarin has a high partition coefficient, which is considered to be favourable for a
rapidabsorption of compounds once they are in an aqueous solution. N-acetyl-l-cysteine showed oppositeresults for the system with 1-octanol/water.
Descrição
Palavras-chave
Solubility Solid–liquid equilibrium Ionic liquids Thermochemical properties Partition coefficient
Contexto Educativo
Citação
Santos, Ana D. dos; Morais, Ana R.C.; Melo, C.; Bogel-Lukasik, R.; Bogel-Lukasik, E. Solubility of pharmaceutical compounds in ionic liquids. In: Fluid Phase Equilibria, Vol. 356, p. 18-29