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Insights on the safety of carotenogenic Chlorella vulgaris in rodents

2013Journal article Open access
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dc.contributor.authorSampayo, C.
dc.contributor.authorCorvo, M. L.
dc.contributor.authorMendes, Rogério
dc.contributor.authorDuarte, D.
dc.contributor.authorLucas, Joana
dc.contributor.authorPinto, R.
dc.contributor.authorBatista, Ana Paula
dc.contributor.authorRaymundo, Anabela
dc.contributor.authorLima, B. Silva
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorGouveia, Luisa
dc.date.accessioned2014-03-11T15:46:55Z
dc.date.available2014-03-11T15:46:55Z
dc.date.issued2013
dc.description.abstractChlorella vulgaris (Cv) biomass is widely used as a traditional food in the Orient and its safety for human consumption has been proved. However, carotenogenic biomass (orange), resulting from induced stresses, needs further safety evaluation, which is the aim of this study. The preliminary toxicological characterization of Cv consisted of a single dose (mice), repeated dose studies (mice and rats) and a biodisposition evaluation (rats). Nomortalities nor relevant clinical signs or behavioural changeswere observed inmice or in rats. The carotenoids in the rat faecal matter suggest that the carotenoids contained in Cv have been absorbed through a potentially saturated transport across the intestinalwall. No safety concerns were identified based on clinical signs, biochemical parameters, and liver and spleen histopathology. No significant differences in food/water intake, blood-pressure, blood glucose levels, glucose tolerance and plasticity of erythrocytes were observed over one month with both supplemented and control animals. The intake of carotenogenic Cv did not reveal any signs of toxicity for doses far exceeding the proposed carotenoid human-diet dose. Therefore these preliminary results suggest that the orange Cv microalgae can be used as a source of carotenoids and could be used for human consumption with possible health benefits.por
dc.identifier.citationSampayo, C.; Corvo, M.L.; Mendes, R.; Duarte, D.; Lucas, J.; Pinto, R.; Batistas, A.P.; Raymundo, A.; Lima, B.S.; Bandarra, N.M.; Gouveia, L. Insights on the safety of carotenogenic Chlorella vulgaris in rodents. In: Algal Research, 2013, Vol. 2, p. 409-415por
dc.identifier.issn2211-9264
dc.identifier.urihttp://hdl.handle.net/10400.9/2291
dc.language.isoengpor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.algal.2013.07.005por
dc.subjectChlorella Vulgarispor
dc.subjectSafetypor
dc.subjectBiodispositionpor
dc.subjectMicroalgapor
dc.subjectCarotenoidspor
dc.titleInsights on the safety of carotenogenic Chlorella vulgaris in rodentspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage415por
oaire.citation.startPage409por
oaire.citation.titleAlgal Researchpor
oaire.citation.volume2por
person.familyNameGouveia
person.givenNameLuisa
person.identifierH-4046-2011
person.identifier.ciencia-id581B-924A-84DD
person.identifier.orcid0000-0003-0196-6360
person.identifier.scopus-author-id7004135834
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication63dcbe08-14df-4886-98b7-2945cbe0e062
relation.isAuthorOfPublication.latestForDiscovery63dcbe08-14df-4886-98b7-2945cbe0e062

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