Publication
Novel insights for permeant lead structures through in vitro skin diffusion assays of Prunus lusitanica L., the Portugal Laurel
| dc.contributor.author | Costa, Maria do Céu | |
| dc.contributor.author | Duarte, Patrícia | |
| dc.contributor.author | Neng, N. R. | |
| dc.contributor.author | Nogueira, J. M. F. | |
| dc.contributor.author | Costa, M. Filomena | |
| dc.contributor.author | Rosado, Catarina | |
| dc.date.accessioned | 2016-04-28T15:34:20Z | |
| dc.date.available | 2016-04-28T15:34:20Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | As a contribution for the generation of libraries in which a natural product (NP) is used as the guiding structure, this work sought to investigate molecular features of triterpenes as deliver leads to cross the stratum corneum at a significant rate. Seeking a bioguided investigation of the dermocosmetic lead-like potential of triterpenes in Prunus lusitanica L., various extracts were obtained by two different methods (Soxhlet extractor and Accelerated Solvent Extraction-ASE) and analyzed by GC–MS and NMR. In vitro assays were conducted to quantify the friedelin 1 and crude plant extract permeation through a membrane of polydimethylsiloxane (PDMS), as well as their skin penetration enhancement capacity using two model molecules, caffeine 19 and ibuprofen 20. Friedelin 1 was identified as the major component (16–77%, GC) with isolated yield of 51% w/w (94%, GC) from Soxhlet residue (1.7% p/p) of the dried aerial parts of the plant harvested when in early flowering stage. Friedelin 1 promoted the penetration of the lipophilic molecule 20, however, it did not influence the permeation of the hydrophilic permeant 20. On the other hand, the crude extract acted as a retardant of the penetration of both substances. Molecular characteristics for the applicability of P. lusitanica L. in the development of dermocosmetics, as well as a new potential use for friedelin 1 in particular, are demonstrated. Probable mechanisms for chemical penetration enhancement using triterpenes as models for transdermal administration are herein discussed. | pt_PT |
| dc.identifier.citation | Costa, M. do Céu; Duarte, P.; Neng, N.R. [et.al.]. - Novel insights for permeant lead structures through in vitro skin diffusion assays of Prunus lusitanica L., the Portugal Laurel. In: Journal of Molecular Structure, 2015, Vol. 1079, p. 327-336 | pt_PT |
| dc.identifier.doi | 10.1016/j.molstruc.2014.08.027 | pt_PT |
| dc.identifier.issn | 0022-2860 | |
| dc.identifier.uri | http://hdl.handle.net/10400.9/2953 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | http://dx.doi.org/10.1016/j.molstruc.2014.08.027 | pt_PT |
| dc.subject | Natural products | pt_PT |
| dc.subject | Prunus lusitanica L. | pt_PT |
| dc.title | Novel insights for permeant lead structures through in vitro skin diffusion assays of Prunus lusitanica L., the Portugal Laurel | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 336 | pt_PT |
| oaire.citation.startPage | 327 | pt_PT |
| oaire.citation.title | Journal of Molecular Structure | pt_PT |
| oaire.citation.volume | 1079 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |