Browsing by Author "Melo, Catarina I."
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- Ammonium ionic liquids as green solvents for drugsPublication . Melo, Catarina I.; Lukasik, Rafal M.; Ponte, Manuel Nunes; Bogel-Lukasik, EwaA high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and corresponding enthalpies for both isoniazid and pyrazinecarboxamide as well as for three ammonium salts were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in analysed ILs was found to be higher than that of pyrazinecarboxamide. Considering ammonium salts examined in this work, didecyldimethylammonium nitrate is the best solvent for both antibiotics. The solid–liquid phase equilibria were described using six different correlation equations which revealed a relatively good description with an acceptable standard deviation temperature range.
- Combination of supercritical carbon dioxide and ionic liquid in a novel assembly of carvacrolPublication . Melo, Catarina I.; Lukasik, Rafal M.; Bogel-Lukasik, EwaExploitation of neoteric solvents in the efficient total synthesis of carvacrol, an antimicrobial reagent, has been accomplished. The first reaction aimed supercritical mediated heterogeneous hydrogenation of carvone catalysed by palladium. The second step guided to an application of great salvation capacity of ionic liquids in separation of carvacrol from the post-hydrogenation mixture. The process has been completed by use of a high pressure CO2 potential to extract carvacrol from the ionic liquid reservoir.
- A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solventsPublication . Forte, Andreia; Melo, Catarina I.; Lukasik, Rafal M.; Bogel-Lukasik, EwaThe sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid–liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range.
- Solubility of pharmaceutical compounds in ionic liquidsPublication . Santos, Ana Duarte dos; Morais, Ana Rita C.; Melo, Catarina I.; Lukasik, Rafal M.; Bogel-Lukasik, EwaThe solubility of N-acetyl-l-cysteine, coumarin and 4-hydroxycoumarin in alternative solvents was studied in this work. The solid–liquid equilibrium (SLE) measurements have been performed using a dynamic(synthetic) method. Melting points and enthalpies of fusion of the pharmaceutical compounds were acquired using a differential scanning calorimetry (DSC). The solubility of N-acetyl-l-cysteine and 4-hydroxycoumarin in trifluoromethanesulfonate ionic liquids was found to be significantly higher thanin the studied bis(trifluoromethylsulfonyl)amide ionic liquids while coumarin exhibited the oppositebehaviour.The solid–liquid phase equilibria were described using the six different correlation equations whichrevealed a good description with an acceptable standard deviation temperature range.Moreover, the solubility data were used to calculate the 1-octanol/water partition coefficients of thestudied drugs. Coumarin has a high partition coefficient, which is considered to be favourable for a rapidabsorption of compounds once they are in an aqueous solution. N-acetyl-l-cysteine showed oppositeresults for the system with 1-octanol/water.
- Supported metal catalysts for free fatty acid rich residuesPublication . Melo, Catarina I.; Scotti, N.; Zaccheria, F.; Lukasik, Rafal M.; Ravasio, N.