Browsing by Author "Neves, M."
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- New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synthesis and CharacterizationPublication . Teixeira, Fatima; Lucas, Carla; Curto, Maria João Marcelo; Neves, M.; Duarte, M. Teresa; Andre, Vania; Teixeira, António P. S.A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.
- New indazolebisphosphonates for bone targeted radiotherapy: synthesis, radiolabeling, in vitro and in vivo studiesPublication . Neves, M.; Gano, L.; Teixeira, Fatima; Antunes, Inês F.; Santos, A.; Majkowska, A.; Bilewicz, A.
- New substituted indazole and condensed pyrazole bisphosphonetesPublication . Teixeira, Fatima; Lucas, Carla; Curto, Maria João Marcelo; Neves, M.; Duarte, M. Teresa; Andre, Vania
- Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterizationPublication . Teixeira, Fatima; Antunes, Inês F.; Curto, Maria João Marcelo; Neves, M.; Teixeira, António P. S.Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between the indazole ring and the bisphosphonate group.
- Synthesis and characterization of novel hydroxy- and aminobisphosphonatesPublication . Teixeira, Fatima; Lucas, Carla; Pereira, Inês F. A.; Curto, Maria João Marcelo; Neves, M.; Duarte, M. TeresaBisphosphonates (BPs) are a family of drugs that are successfully used in the treatment of various calcium-related disorders such as Pagetμs disease, osteoporosis and bone metastases. In addition, functional BPs have been also used in the treatment of metal intoxication and as novel ligands for well-defined radioactive metal complexes that can be used in imagiology, scintigraphy and radiotherapy applications [1,2]. The indazole derivatives are pharmacologically important compounds and the indazole ring system forms the basis of a number of drug molecules. Condensed pyrazoles are also known as pharmacophoric elements in numerous active compounds. However, in comparison with other heteroaromatic compounds, the chemistry of indazole and condensed pyrazoles remains less studied [3]. The present work is to extend the previous studies in indazolebisphosphonates [4] in order to obtain new BPs derived from indazole and condensed pyrazole with potential biological/therapeutical activities. Herein, we report the synthesis and characterization of a series of new 1-hydroxybisphosphonates (1) and aminobisphosphonates (2) (substituted at different C- or N-positions of the indazole ring - N-1, C-5, C-6, C-7)