Browsing by Issue Date, starting with "2007-11"
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- Integração de processos: a base de uma utilização energeticamente eficiente da Biomassa e a cooperação internacionalPublication . Cabrita, Isabel; Matos, Henrique A.
- Tecnologias de aproveitamento energético de biomassaPublication . Gulyurtlu, Ibrahim
- The relationships between charnockites and associated granitoids of Ribeira Belt : their ages and originsPublication . Tassinari, Colombo C. G.; Munhá, José; Bento dos Santos, Telmo; Neto, Coriolano Dias; Palácios, Teresa; Fonseca, Paulo E.
- A fórmula da cortiçaPublication . Gil, Luís; Pereia, CarlosA cortiça é um material natural que é constituído por uma mistura complexa de componentes, compreendendo estes, por sua vez, vários constituintes, muitos de natureza polimérica. Não há conhecimento da sua fórmula estequiométrica ter sido publicada, sendo determinada neste trabalho. O seu conhecimento é necessário, entre outros aspectos, para estudos no campo da medicina. No presente trabalho determinámos a fórmula estequiométrica aproximada da cortiça utilizando como base uma técnica específica, a análise elementar. Para tal foram utilizados quatro tipos de diferentes de cortiça (2 cortiças de reprodução e 2 cortiças virgens) para assegurarmos uma maior representatividade do resultado médio obtido.
- Infrared spectroscopic studies of novel hydroxybisphosphonates and molecular modelling of their interaction with hydroxyapatitePublication . Duarte, L.; Teixeira, Fatima; Fausto, R.Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption, including osteoporosis, Paget’s disease and metastic bone disease [1]. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb to bone mineral is also an important factor in determining their potency and duration of action [2]. In this study, we performed a molecular modelling analysis, by molecular mechanics, of the molecular structures of hydroxy(1H-indazol-3-yl)methylenediphosphonic acid (BP1; Figure 1a) and hydroxy(1-methyl-1H-indazol-3-yl)methylenediphosphonic acid (BP2; Figure 1b) and examined their interactions with hydroxyapatite (HA) by energy-minimising 50 different orientations for judiciously selected low energy conformers of each ligand at 10 Å from the mineral surface. We also calculated the vibrational spectra for each BP with semiempirical methods and compared then with FTIR spectra obtained experimentaly. The calculated interaction energies of the studied BPs with HA suggests that BP2 interacts stronger with hydroxyapatite than BP1. These results are in agreement with in vitro and in vivo studies of the 153Sm-BPs complexes. Complex 153Sm-BP2 showed, in vitro, higher HA binding than complex 153Sm-BP1. In vivo studies showed different farmacokinetics parameters with complex 153Sm-BP2 presenting initial higher levels of bone uptake than complex 153Sm-BP1, which concentration is increasing during the 24 h period studied.
- Los Edificios en el Futuro, Estrategias Bioclimáticas y Sustentabilidad : Livro de Ponencias del SeminarioPublication . Goncalves, Helder; Camelo, Susana