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A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites

2018-12Journal article Open access
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dc.contributor.authorHoek, Gerard
dc.contributor.authorRanzi, Andrea
dc.contributor.authorAlimehmeti, Ilir
dc.contributor.authorArdeleanu, Elena-Roxana
dc.contributor.authorArrebola, Juan P.
dc.contributor.authorÁvila, Paula Freire
dc.contributor.authorCandeias, Carla
dc.contributor.authorColles, Ann
dc.contributor.authorCrisan, Gloria Cerasela
dc.contributor.authorDack, Sarah
dc.contributor.authorDemeter, Zoltan
dc.contributor.authorFazzo, Lucia
dc.contributor.authorFierens, Tine
dc.contributor.authorFluckiger, Benjamin
dc.contributor.authorGaengler, Stephanie
dc.contributor.authorHanninen, Otto
dc.contributor.authorHarzia, Hedi
dc.contributor.authorHough, Rupert
dc.contributor.authorIantovics, Barna Laszlo
dc.contributor.authorKalantzi, Olga-Ioanna
dc.contributor.authorKarakitsios, Spyros P.
dc.contributor.authorMakris, Konstantinos C.
dc.contributor.authorMartin-Olmedo, Piedad
dc.contributor.authorNechita, Elena
dc.contributor.authorNicoli, Thomai
dc.contributor.authorOrru, Hans
dc.contributor.authorPasetto, Roberto
dc.contributor.authorPerez-Carrascosa, F.M.
dc.contributor.authorPestana, Diogo
dc.contributor.authorRocha, Fernando
dc.contributor.authorSarigiannis, Dimosthenis A.
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorTsadilas, Christos
dc.contributor.authorTasic, Visa
dc.contributor.authorVaccari, Lorenzo
dc.contributor.authorIavarone, Ivano
dc.contributor.authorde Hoogh, Kees
dc.date.accessioned2022-04-05T14:23:41Z
dc.date.available2022-04-05T14:23:41Z
dc.date.issued2018-12
dc.description.abstractABSTRACT: BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessment of single contaminants is the main approach to assess health risks, but epidemiological studies which investigate the relationships between exposure and health directly in the affected population have contributed important evidence. Limitations in exposure assessment have substantially contributed to uncertainty about associations found in epidemiological studies. OBJECTIVES: to examine exposure assessment methods that have been used in epidemiological studies on ICSs and to provide recommendations for improved exposure assessment in epidemiological studies by comparing exposure assessment methods in epidemiological studies and risk assessments. METHODS: after defining the multi-media framework of exposure related to ICSs, we discussed selected multi-media models applied in Europe. We provided an overview of exposure assessment in 54 epidemiological studies from a systematic review of hazardous waste sites; a systematic review of 41 epidemiological studies on incinerators and 52 additional studies on ICSs and health identified for this review. RESULTS: we identified 10 multi-media models used in Europe primarily for risk assessment. Recent models incorporated estimation of internal biomarker levels. Predictions of the models differ particularly for the routes 'indoor air inhalation' and 'vegetable consumption'. Virtually all of the 54 hazardous waste studies used proximity indicators of exposure, based on municipality or zip code of residence (28 studies) or distance to a contaminated site (25 studies). One study used human biomonitoring. In virtually all epidemiological studies, actual land use was ignored. In the 52 additional studies on contaminated sites, proximity indicators were applied in 39 studies, air pollution dispersion modelling in 6 studies, and human biomonitoring in 9 studies. Exposure assessment in epidemiological studies on incinerators included indicators (presence of source in municipality and distance to the incinerator) and air dispersion modelling. Environmental multi-media modelling methods were not applied in any of the three groups of studies. CONCLUSIONS: recommendations for refined exposure assessment in epidemiological studies included the use of more sophisticated exposure metrics instead of simple proximity indicators where feasible, as distance from a source results in misclassification of exposure as it ignores key determinants of environmental fate and transport, source characteristics, land use, and human consumption behaviour. More validation studies using personal exposure or human biomonitoring are needed to assess misclassification of exposure. Exposure assessment should take more advantage of the detailed multi-media exposure assessment procedures developed for risk assessment. The use of indicators can be substantially improved by linking definition of zones of exposure to existing knowledge of extent of dispersion. Studies should incorporate more often land use and individual behaviour.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHoek, Gerard... [et.al.] - A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites. In: Epidemiologia & Prevenzione, 2018, Vol. 42 (5-6), suppl. 1, pp. 21-36pt_PT
dc.identifier.doi10.19191/EP18.5-6.S1.P021.085pt_PT
dc.identifier.eissn2385-1937
dc.identifier.issn1120-9763
dc.identifier.urihttp://hdl.handle.net/10400.9/3819
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInferenze scarlpt_PT
dc.relation.publisherversionhttps://doi.org/10.19191/EP18.5-6.S1.P021.085pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEpidemiologypt_PT
dc.subjectContaminated sitespt_PT
dc.subjectEnvironmental pollutionpt_PT
dc.subjectExposure assessmentpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectRisk assessmentpt_PT
dc.titleA review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage36pt_PT
oaire.citation.issue5-6pt_PT
oaire.citation.startPage21pt_PT
oaire.citation.titleEpidemiologia & Prevenzionept_PT
oaire.citation.volume42pt_PT
person.familyNameÁvila
person.familyNameCandeias
person.familyNameRocha
person.givenNamePaula
person.givenNameCarla
person.givenNameFernando
person.identifier.ciencia-idD912-6FC4-79CC
person.identifier.ciencia-id6F13-70A2-3998
person.identifier.orcid0000-0002-4080-0737
person.identifier.orcid0000-0001-6664-8545
person.identifier.orcid0000-0002-3636-3933
person.identifier.ridB-2774-2014
person.identifier.ridA-2521-2014
person.identifier.ridA-4532-2009
person.identifier.scopus-author-id37062910200
person.identifier.scopus-author-id8626859600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery8ae5b98e-08fe-4091-a8c7-a18a501bb150

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