Publication
Simulation of immune system response to bacterial challenge
| dc.contributor.author | Fachada, Nuno | |
| dc.contributor.author | Lopes, Vitor V. | |
| dc.contributor.author | Rosa, Agostinho | |
| dc.date.accessioned | 2010-06-24T09:58:13Z | |
| dc.date.available | 2010-06-24T09:58:13Z | |
| dc.date.issued | 2008-10-27 | |
| dc.description.abstract | Immune system (IS) simulations have several applications, such as biological theory testing or as a complement in the development of improved drugs. This paper presents an agent based approach to simulate the IS response to bacterial infection challenge. The agent simulator is implemented in a discrete time and twodimensional space, and composed by two layers: a) a specialized cellular automata responsible for substance di usion and reactions; and b) the layer where agents move, act and interact. The IS model focuses upon low level cellular receptor interactions, receptor diversity and genetic-ruled agents, aiming to observe and study the resultant emergent behavior. The model reproduces the following IS behavioral characteristics: speci city and specialization, immune memory and vaccine immunization. | pt |
| dc.identifier.citation | Fachada, N.; Lopes, Vitor V.; Rosa, Agostinho. Simulation of immune system response to bacterial challenge. In: ESM 2008 - European Simulation and Modelling, Université du Havre, Le Havre, France, October 27-29, 2008, p. 252-257 | pt |
| dc.identifier.uri | http://hdl.handle.net/10400.9/707 | |
| dc.language.iso | eng | pt |
| dc.subject | Modelling | pt |
| dc.subject | Simulation | pt |
| dc.subject | Agents | pt |
| dc.subject | Immune System | pt |
| dc.title | Simulation of immune system response to bacterial challenge | pt |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Le Havre, France | pt |
| oaire.citation.title | ESM 2008 - European Simulation and Modelling, | pt |
| rcaap.rights | openAccess | pt |
| rcaap.type | conferenceObject | pt |