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Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage

2018Journal article Open access
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dc.contributor.authorGonçalves, Carla
dc.contributor.authorWisecaver, Jennifer H.
dc.contributor.authorKominek, Jacek
dc.contributor.authorOom, Madalena Salema
dc.contributor.authorLeandro, Maria José
dc.contributor.authorShen, Xing-Xing
dc.contributor.authorOpulente, Dana A.
dc.contributor.authorZhou, Xiaofan
dc.contributor.authorPeris, David
dc.contributor.authorKurtzman, Cletus P.
dc.contributor.authorHittinger, Chris Todd
dc.contributor.authorRokas, Antonis
dc.contributor.authorGonçalves, Paula
dc.date.accessioned2018-09-07T14:33:37Z
dc.date.available2018-09-07T14:33:37Z
dc.date.issued2018
dc.description.abstractABSTRACT: Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; [et.al.]. - Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage. In: eLife, 2018, Vol. 7, p. 1-28pt_PT
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/10400.9/3051
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.relationImprovement of fructose fermentation by industrial Saccharomyces cerevisiae strains
dc.relationEngineering yeast for efficient co-fermentation of mixed sugars: advantages for ethanol production in the food and fuel industries
dc.relation.publisherversionhttps://doi.org/10.7554/eLife.33034pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlcoholic fermentationpt_PT
dc.subjectYeastspt_PT
dc.subjectFructophilic bacteriumpt_PT
dc.titleEvidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleImprovement of fructose fermentation by industrial Saccharomyces cerevisiae strains
oaire.awardTitleEngineering yeast for efficient co-fermentation of mixed sugars: advantages for ethanol production in the food and fuel industries
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F112802%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89489%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F102803%2F2014/PT
oaire.citation.endPage28pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleeLifept_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameTravassos Leandro
person.givenNameMaria José
person.identifierK-5461-2015
person.identifier.ciencia-idE91B-D158-3535
person.identifier.orcid0000-0002-2254-4610
person.identifier.scopus-author-id36854236300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery846fa2db-9af3-44d1-8b91-aa0f128a3da9
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