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In vitro toxicity of arsenic rich waters from an abandoned gold mine in northeast Portugal

2021-07Journal article Open access
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dc.contributor.authorCosta, Maria
dc.contributor.authorGošar, Doroteja
dc.contributor.authorPinti, Marika
dc.contributor.authorFerreira, Adelaide
dc.contributor.authorMarušič, Martina Bergant
dc.date.accessioned2022-01-20T16:30:57Z
dc.date.available2023-07-01T00:30:19Z
dc.date.issued2021-07
dc.description.abstractABSTRACT: This is a follow-up study of physicochemical water monitoring data from the abandoned Freixeda gold mine in Portugal, where arsenic (As) has remained above drinking water and irrigation limits over the years. The main objective of the current work was to investigate the toxicological potential of As-containing water on human cell line as an indicator of a potential health risk to humans. Six water samples collected in February 2018 were analysed for arsenic, major anions, cations and trace elements. Toxicity experiments were carried out on the human gastrointestinal cell line Caco-2 with five water samples containing As above 10 μg L−1. The results show that groundwater contains higher amounts of dissolved minerals than surface water, particularly with higher concentrations of SO42−, Fe and HCO3− and also higher As(III), reaching 336 μg L−1 (As(T) = 607 μg L−1). In surface waters As concentration decreased and reached 150 μg L−1, mainly as As(V). Metabolic activity was generally lower in Caco-2 cells exposed to As-containing water samples compared to pure As(III) solution, adapted to As concentrations, while production of reactive oxygen species (ROS) was higher. Short-term exposure to As-contaminated water samples also resulted in increased genotoxicity. This study suggests that mixture of As with various chemical elements in water may have a synergistic effect in promoting cytotoxicity. It is likely that prolonged exposure, as is common in areas with contaminated water, would have even more harmful effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta et al. 2021, ‘In vitro toxicity of arsenic rich waters from an abandoned gold mine in northeast Portugal’, Environmental Research, vol. 202, article 111683. doi:10.1016/j.envres.2021.111683pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.envres.2021.111683pt_PT
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.9/3714
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSlovenian Research Agency, Research program Analytics and Chemical Characterization of Materials and Processes [grant number P1-0034].pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935121009774pt_PT
dc.subjectArsenicpt_PT
dc.subjectWater contaminationpt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectCaco-2 cellspt_PT
dc.titleIn vitro toxicity of arsenic rich waters from an abandoned gold mine in northeast Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume202pt_PT
person.familyNameCosta
person.givenNameMaria
person.identifier.ciencia-idDD1B-DEC9-43AC
person.identifier.orcid0000-0002-4283-8712
person.identifier.ridL-3570-2013
person.identifier.scopus-author-id55969710500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione3b24f35-4617-47ff-ab16-3f4b8b055aa1
relation.isAuthorOfPublication.latestForDiscoverye3b24f35-4617-47ff-ab16-3f4b8b055aa1

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