Repository logo
 
Publication

Synthesis and characterization of novel hydroxy- and aminobisphosphonates

2007-07-16Conference object Open access
Simple item page
dc.contributor.authorTeixeira, Fatima
dc.contributor.authorLucas, Carla
dc.contributor.authorPereira, InĆŖs F. A.
dc.contributor.authorCurto, Maria JoĆ£o Marcelo
dc.contributor.authorNeves, M.
dc.contributor.authorDuarte, M. Teresa
dc.date.accessioned2010-07-08T10:59:46Z
dc.date.available2010-07-08T10:59:46Z
dc.date.issued2007-07-16
dc.description.abstractBisphosphonates (BPs) are a family of drugs that are successfully used in the treatment of various calcium-related disorders such as PagetĪ¼s disease, osteoporosis and bone metastases. In addition, functional BPs have been also used in the treatment of metal intoxication and as novel ligands for well-defined radioactive metal complexes that can be used in imagiology, scintigraphy and radiotherapy applications [1,2]. The indazole derivatives are pharmacologically important compounds and the indazole ring system forms the basis of a number of drug molecules. Condensed pyrazoles are also known as pharmacophoric elements in numerous active compounds. However, in comparison with other heteroaromatic compounds, the chemistry of indazole and condensed pyrazoles remains less studied [3]. The present work is to extend the previous studies in indazolebisphosphonates [4] in order to obtain new BPs derived from indazole and condensed pyrazole with potential biological/therapeutical activities. Herein, we report the synthesis and characterization of a series of new 1-hydroxybisphosphonates (1) and aminobisphosphonates (2) (substituted at different C- or N-positions of the indazole ring - N-1, C-5, C-6, C-7)pt
dc.identifier.citationTeixeira, F. C.; Lucas, C.; Pereira, I. F. A.; Curto, M. J. M.; Neves, M.; Duarte, M. T. Synthesis and characterization of novel hydroxy- and aminobisphosphonates. In: 7ENQQ, 7Āŗ Encontro Nacional de QuĆ­mica OrgĆ¢nica e 1Āŗ SimpĆ³sio Luso-FrancĆŖs de QuĆ­mica OrgĆ¢nica da Sociedade Portuguesa de QuĆ­mica, Lisboa, Julho, 16-18 de 2007, Book of Abstracts, PC 47pt
dc.identifier.urihttp://hdl.handle.net/10400.9/812
dc.language.isoengpt
dc.titleSynthesis and characterization of novel hydroxy- and aminobisphosphonatespt
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt
oaire.citation.title7ENQQ, 7Āŗ Encontro Nacional de QuĆ­mica OrgĆ¢nica e 1Āŗ SimpĆ³sio Luso-FrancĆŖs de QuĆ­mica OrgĆ¢nica da Sociedade Portuguesa de QuĆ­micapt
person.familyNameTeixeira
person.familyNameDuarte
person.givenNameFatima
person.givenNameMaria Teresa
person.identifier1017457
person.identifier.ciencia-idC014-509B-D1DC
person.identifier.ciencia-id7E16-5ED4-ED6A
person.identifier.orcid0000-0003-0801-2068
person.identifier.orcid0000-0003-0994-1352
person.identifier.ridH-8658-2012
person.identifier.scopus-author-id7102746385
person.identifier.scopus-author-id6505770075
rcaap.rightsopenAccesspt
rcaap.typeconferenceObjectpt
relation.isAuthorOfPublication3daa40f1-7bb6-488d-83d9-04a61c655d67
relation.isAuthorOfPublicationd5330a18-4020-4221-a577-b79c4ac6facf
relation.isAuthorOfPublication.latestForDiscovery3daa40f1-7bb6-488d-83d9-04a61c655d67

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SYNTHECHARACTERIZ.pdf
Size:
81.37 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.8 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

INETI - Resumos publicados em Livros de Actas