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- Rethinking the old and trustworthy: new drugs for TBPublication . Figueiredo, Ricardo; Costa, Maria do Céu; Menezes, J. C.
- Variable-temperature 1H-NMR studies on the conformations of N’-palmitoyl-rifabutin in solutionPublication . Figueiredo, Ricardo; Duarte, Maria L.; Rodrigues, A. I.; Costa, Maria do Céu; Menezes, J. C.
- Organic resins functionalized with chiral salen complexes as heterogeneous catalysts for the strecker reactionPublication . Esteves, M. Alexandra; Santos, Célia; Guerreiro, A. Margarida; Baleizão, Carlos
- Synthesis and characterization of novel hydroxy- and aminobisphosphonatesPublication . Teixeira, Fatima; Lucas, Carla; Pereira, Inês F. A.; Curto, Maria João Marcelo; Neves, M.; Duarte, M. TeresaBisphosphonates (BPs) are a family of drugs that are successfully used in the treatment of various calcium-related disorders such as Pagetμs disease, osteoporosis and bone metastases. In addition, functional BPs have been also used in the treatment of metal intoxication and as novel ligands for well-defined radioactive metal complexes that can be used in imagiology, scintigraphy and radiotherapy applications [1,2]. The indazole derivatives are pharmacologically important compounds and the indazole ring system forms the basis of a number of drug molecules. Condensed pyrazoles are also known as pharmacophoric elements in numerous active compounds. However, in comparison with other heteroaromatic compounds, the chemistry of indazole and condensed pyrazoles remains less studied [3]. The present work is to extend the previous studies in indazolebisphosphonates [4] in order to obtain new BPs derived from indazole and condensed pyrazole with potential biological/therapeutical activities. Herein, we report the synthesis and characterization of a series of new 1-hydroxybisphosphonates (1) and aminobisphosphonates (2) (substituted at different C- or N-positions of the indazole ring - N-1, C-5, C-6, C-7)
- Antimicrobial activity of azorean cryptomeria japonica essential oils.Publication . Moiteiro, Cristina; Feio, Sónia; Rojas, R.; Bragança, H.
- Tuberculostatic activity of marine sesquiterpene (S)-(+)-curcuphenol and semisynthetic derivatesPublication . Moiteiro, Cristina; Gaspar, Helena; Sardinha, João; Ramos, D.; Silva, P. Almeida da
- Plectranthus diterpenes against mycobacterium tuberculosisPublication . Rijo, P.; Simões, M. F.; Francisco, A. P.; Rojas, R.; Gilman, R. H.; Vaisberg, A. J.; Moiteiro, Cristina; Rodriguez, B.
- Perfilometria óptica baseada em recuperação de fase.Publication . Coelho, João M. P.; Domingues, C.; Monteiro, Fernando; Abreu, Manuel A.
- Interferometria no infravermelho médioPublication . Silva, Catarina; Coelho, João M. P.; Monteiro, Fernando; Abreu, Manuel A.; Rebordão, José Manuel
- Modelação do aquecimento de células por radiação laserPublication . Vilhena, H.; Coelho, João M. P.; Rebordão, José Manuel