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Asymmetric synthesis of secondary benzylic alcohols via arene chromium tricarbonyl complexes
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Orientador(es)
Resumo(s)
ABSTRACT: The use of O-methyl-N-(alpha-methylbenzyl)hydroxylamine as a novel chiral auxiliary in asymmetric ortho-deprotonation of the (eta(6)-arene) chromium tricarbonyl complexes is described. Upon quenching of the resultant ortho-lithiated complex with an electrophile, 1,2-disubstituted (eta(6)-arene) chromium tricarbonyl complexes were obtained in good yield and excellent levels of diastereoselectivity.
Descrição
Palavras-chave
Asymmetric synthesis Hydroxylamines Catalysis Organic chemistry
Contexto Educativo
Citação
Costa, M. Rute G. da; Curto, M. João M.; Davies, Stephen G... [et.al.] - Asymmetric synthesis of secondary benzylic alcohols via arene chromium tricarbonyl complexes. In: Tetrahedron, 2018, Vol. 74, p. 5965-5973