Simulating antigenic drift and shift in influenza A

Fachada, Nuno; Lopes, Vitor V.; Rosa, Agostinho

http://hdl.handle.net/10400.9/708

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Authors

Fachada, Nuno

Lopes, Vitor V.

Rosa, Agostinho

Abstract(s)

Computational models of the immune system and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present an agent-based model of immune-influenza A dynamics, with focus on low level molecular antigen-antibody interactions, in order to study antigenic drift and shift events, and analyze the virulence of emergent strains. At this stage of the investigation, results are presented and discussed from a qualitative point of view against recent and generally recognized immunology and influenza literature.

Keywords

Immune system Influenza A Simulation Agent-based modeling

URI

http://hdl.handle.net/10400.9/708

Citation

Fachada, N.; Lopes, Vitor V.; Rosa, Agostinho. Simulating antigenic drift and shift in influenza A. In: Proceeding of the 24th Annual ACM Symposium on Applied Computing (SAC'2009), Honolulu, Hawaii, USA. ACM, 8-12 March 2009, p. 2093-2100

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ISE - Comunicações em actas de encontros científicos internacionais

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