Publication
Simulating antigenic drift and shift in influenza A
| dc.contributor.author | Fachada, Nuno | |
| dc.contributor.author | Lopes, Vitor V. | |
| dc.contributor.author | Rosa, Agostinho | |
| dc.date.accessioned | 2010-06-24T10:24:08Z | |
| dc.date.available | 2010-06-24T10:24:08Z | |
| dc.date.issued | 2009-03-08 | |
| dc.description.abstract | Computational models of the immune system and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present an agent-based model of immune-influenza A dynamics, with focus on low level molecular antigen-antibody interactions, in order to study antigenic drift and shift events, and analyze the virulence of emergent strains. At this stage of the investigation, results are presented and discussed from a qualitative point of view against recent and generally recognized immunology and influenza literature. | pt |
| dc.identifier.citation | Fachada, N.; Lopes, Vitor V.; Rosa, Agostinho. Simulating antigenic drift and shift in influenza A. In: Proceeding of the 24th Annual ACM Symposium on Applied Computing (SAC'2009), Honolulu, Hawaii, USA. ACM, 8-12 March 2009, p. 2093-2100 | pt |
| dc.identifier.uri | http://hdl.handle.net/10400.9/708 | |
| dc.language.iso | eng | pt |
| dc.subject | Immune system | pt |
| dc.subject | Influenza A | pt |
| dc.subject | Simulation | pt |
| dc.subject | Agent-based modeling | pt |
| dc.title | Simulating antigenic drift and shift in influenza A | pt |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Honululu, Hawaii | pt |
| oaire.citation.title | 24th Annual ACM Symposium on Applied Computing (SAC'2009), Honolulu, Hawaii | pt |
| rcaap.rights | openAccess | pt |
| rcaap.type | conferenceObject | pt |